-weighted dynamic contrast-enhanced MRI voxel-by-voxel Gd concentration maps of Gd-dendrimer distribution over time within large orthotopic RG-2 malignant brain tumors. The volume, in mm3, for each large orthotopic RG-2 glioma: Gd-G1, 104; Gd-G2, 94; Gd-G3, 94; lowly conjugated (LC) Gd-G4, 162; standard Gd-G4, 200; Gd-G5, 230; Gd-G6, 201; Gd-G7, 170; and Gd-G8, 289. Respective Gd-dendrimer generations administered intravenously over 1 minute at a Gd dose of 0.09 mmol Gd/kg animal body weight. Scale from 0 mM [Gd] to 0.1 mM [Gd]. Adapted from references [3,8,28].