Figure 4
T 1 -weighted dynamic contrast-enhanced MRI Gd voxel-by-voxel Gd concentration maps of Gd-dendrimer distribution over time within small orthotopic RG-2 malignant brain tumors. The volume, in mm3, for each small orthotopic RG-2 glioma: Gd-G1, 27; Gd-G2, 28; Gd-G3, 19; lowly conjugated (LC) Gd-G4, 24; standard Gd-G4, 17; Gd-G5, 18; Gd-G6, 22; Gd-G7, 24; and Gd-G8, 107. Respective Gd-dendrimer generations administered intravenously over 1Â minute at a Gd dose of 0.09Â mmol Gd/kg animal body weight. Scale from 0Â mM [Gd] to 0.1Â mM [Gd]. Adapted from references [3,8,28].