Figure 6

T ₂ –weighted anatomical MRI images and T ₁ -weighted dynamic contrast-enhanced MRI voxel-by-voxel Gd concentration maps of higher generation Gd-dendrimer distribution over approximately 3 hours within orthotopic and ectopic RG-2 malignant solid tumors. The volume, in mm³, for each orthotopic and ectopic RG-2 glioma: First row, Gd-G5; 45 mm³ (brain), 113 mm³ (peripheral); Second row, Gd-G6; 97 mm³ (brain), 184 mm³ (peripheral); Third row, Gd-G7; 53 mm³ (brain), 135 mm³ (peripheral); Fourth row, Gd-G8; 50 mm³ (brain); 163 mm³ (peripheral). Respective Gd-dendrimer generations administered intravenously over 1 minute at a Gd dose of 0.09 mmol Gd/kg animal body weight. Scale from 0.00 mM [Gd] to 0.15 mM [Gd]. Adapted from references [8,29].