Figure 8

T ₂ -weighted anatomic MRI scan image of an orthotopic RG-2 malignant brain tumor and T ₁ -weighted dynamic contrast-enhanced MRI voxel-by-voxel Gd concentration maps at baseline and at 60 minutes following Gd-G5-doxorubicin dendrimer infusion. Red arrow highlights non-selective contrast enhancement in normal brain tissue. The Gd-G5-doxorubicin dendrimer administered intravenously over 2 minutes at a Gd dose of 0.09 mmol Gd/kg animal body weight, which is equivalent to a doxorubicin dose of 8 mg/kg animal body weight. Scale from 0 mM [Gd] to 0.2 mM [Gd]. Adapted from reference [3,8].