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Table 1 Biophysical properties of naked dendrimers and functionalized dendrimer-based theranostic nanoparticles

From: Translational theranostic methodology for diagnostic imaging and the concomitant treatment of malignant solid tumors

Polyamidoamine dendrimer (G)

Terminal groups (#)

Naked dendrimer weight (kDa)

Naked dendrimer size (nm) &

Gd-DTPA conjugation (%)~1

Small molecule drug conjugation (%)~2

Funtionalized dendrimer weight (kDa)^

Gd-DTPA dendrimer size (nm)

Theranostic dedrimer size (nm)*

Molar relaxivity (r:ms-1/mM)

Gt-dtpa-G1

8

1.43

1.9

67.1

 

5.63

  

9.8

Gt-dtpa-G2

16

3.26

2.6

65.9

 

11.2

  

10.1

Gt-dtpa-G3

32

6.91

3.6

47.7

 

18.6

  

10.4

Low Gd-dtpa-G4

64

14.2

4.4

29.8

 

24.4

  

7.8

Std Gd-dtpa-G4

64

14.2

5.7

47.5

 

39.8

  

12.2

Gd-dtpa-G5

128

28.8

est 5.5

47.2

 

79.8

est 7.5

 

109

Theranostic G5

128

28.8

est 5.5

48.1

7.8

85.0

n/a

9

10.1

Gd-dtpa-G6

256

58.0

6.9

39.9

 

133

est 10

 

10.6

Gd-dtpa-G7

512

116

8.0

50

 

330^

11

 

10.3

Gd-dtpa-G8

1024

233

10.3

37.8

 

597^

13

 

9.4

  1. Blank = not available.
  2. G = Dendrimer Genaration.
  3. & = Combination of outside data from Dynamic light scattering and TEM findings of Ref 60 and Dendritic Nanotechnologies,Inc.
  4. ~1 = Based on (MALDI TOF Functionalized Dendrimer Weight - Naked Dendrimer Weight) / 725; Gd-DTPA unit Weight = 725 Daltons.
  5. Doxorubicin (544 Da) + Linker Weight (278 Da) = 822 Daltons (8 Doxorubicin per Funtionalized Dendrimer).
  6. * = Dynamic light scattering measurement for Gd-DTPA-dendrimer-Hydrazone LINKER-Doxorubicin; Otherwise estimated or measured per ADF TEM.
  7. ^ = Measured by ADF TEM; Otherwise measured by MADLI TOF spectroscopy.
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Neurovascular Imaging

ISSN: 2055-5792