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Table 1 Biophysical properties of naked dendrimers and functionalized dendrimer-based theranostic nanoparticles

From: Translational theranostic methodology for diagnostic imaging and the concomitant treatment of malignant solid tumors

Polyamidoamine dendrimer (G) Terminal groups (#) Naked dendrimer weight (kDa) Naked dendrimer size (nm) & Gd-DTPA conjugation (%)~1 Small molecule drug conjugation (%)~2 Funtionalized dendrimer weight (kDa)^ Gd-DTPA dendrimer size (nm) Theranostic dedrimer size (nm)* Molar relaxivity (r:ms-1/mM)
Gt-dtpa-G1 8 1.43 1.9 67.1   5.63    9.8
Gt-dtpa-G2 16 3.26 2.6 65.9   11.2    10.1
Gt-dtpa-G3 32 6.91 3.6 47.7   18.6    10.4
Low Gd-dtpa-G4 64 14.2 4.4 29.8   24.4    7.8
Std Gd-dtpa-G4 64 14.2 5.7 47.5   39.8    12.2
Gd-dtpa-G5 128 28.8 est 5.5 47.2   79.8 est 7.5   109
Theranostic G5 128 28.8 est 5.5 48.1 7.8 85.0 n/a 9 10.1
Gd-dtpa-G6 256 58.0 6.9 39.9   133 est 10   10.6
Gd-dtpa-G7 512 116 8.0 50   330^ 11   10.3
Gd-dtpa-G8 1024 233 10.3 37.8   597^ 13   9.4
  1. Blank = not available.
  2. G = Dendrimer Genaration.
  3. & = Combination of outside data from Dynamic light scattering and TEM findings of Ref 60 and Dendritic Nanotechnologies,Inc.
  4. ~1 = Based on (MALDI TOF Functionalized Dendrimer Weight - Naked Dendrimer Weight) / 725; Gd-DTPA unit Weight = 725 Daltons.
  5. Doxorubicin (544 Da) + Linker Weight (278 Da) = 822 Daltons (8 Doxorubicin per Funtionalized Dendrimer).
  6. * = Dynamic light scattering measurement for Gd-DTPA-dendrimer-Hydrazone LINKER-Doxorubicin; Otherwise estimated or measured per ADF TEM.
  7. ^ = Measured by ADF TEM; Otherwise measured by MADLI TOF spectroscopy.