|
Polyamidoamine dendrimer (G)
|
Terminal groups (#)
|
Naked dendrimer weight (kDa)
|
Naked dendrimer size (nm) &
|
Gd-DTPA conjugation (%)~1
|
Small molecule drug conjugation (%)~2
|
Funtionalized dendrimer weight (kDa)^
|
Gd-DTPA dendrimer size (nm)
|
Theranostic dedrimer size (nm)*
|
Molar relaxivity (r:ms-1/mM)
|
|---|
|
Gt-dtpa-G1
|
8
|
1.43
|
1.9
|
67.1
| |
5.63
| | |
9.8
|
|
Gt-dtpa-G2
|
16
|
3.26
|
2.6
|
65.9
| |
11.2
| | |
10.1
|
|
Gt-dtpa-G3
|
32
|
6.91
|
3.6
|
47.7
| |
18.6
| | |
10.4
|
|
Low Gd-dtpa-G4
|
64
|
14.2
|
4.4
|
29.8
| |
24.4
| | |
7.8
|
|
Std Gd-dtpa-G4
|
64
|
14.2
|
5.7
|
47.5
| |
39.8
| | |
12.2
|
|
Gd-dtpa-G5
|
128
|
28.8
|
est 5.5
|
47.2
| |
79.8
|
est 7.5
| |
109
|
|
Theranostic G5
|
128
|
28.8
|
est 5.5
|
48.1
|
7.8
|
85.0
|
n/a
|
9
|
10.1
|
|
Gd-dtpa-G6
|
256
|
58.0
|
6.9
|
39.9
| |
133
|
est 10
| |
10.6
|
|
Gd-dtpa-G7
|
512
|
116
|
8.0
|
50
| |
330^
|
11
| |
10.3
|
|
Gd-dtpa-G8
|
1024
|
233
|
10.3
|
37.8
| |
597^
|
13
| |
9.4
|
- Blank = not available.
- G = Dendrimer Genaration.
- & = Combination of outside data from Dynamic light scattering and TEM findings of Ref 60 and Dendritic Nanotechnologies,Inc.
- ~1 = Based on (MALDI TOF Functionalized Dendrimer Weight - Naked Dendrimer Weight) / 725; Gd-DTPA unit Weight = 725 Daltons.
- Doxorubicin (544 Da) + Linker Weight (278 Da) = 822 Daltons (8 Doxorubicin per Funtionalized Dendrimer).
- * = Dynamic light scattering measurement for Gd-DTPA-dendrimer-Hydrazone LINKER-Doxorubicin; Otherwise estimated or measured per ADF TEM.
- ^ = Measured by ADF TEM; Otherwise measured by MADLI TOF spectroscopy.
