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Table 1 Study design

From: An historical and contemporary review of endovascular therapy for acute ischemic stroke

  Arms Size Era Centres Age Range Clinical Criteria Vessel occlusion Time Window (onset to groin puncture) CT Criteria Advanced Imaging Criteria
MR RESCUE Rescue EVT v standard 118 2004 - 2011 North America – 22 sites 18-85 yr NIHSS 6- 29 CTA/MRA showing persistent occlusion post IVT – ICA, M1 or M2 <8 hr None Penumbra assessment with multimodal CT or MRI for stratification but not for trial eligibility
IMS III Bridging v IVT 656 Aug 2006 – Apr 2012 58 Centres (US, Canada, Australia, Europe) 18-82 yr NIHSS ≥10 Not required at randomization <5 hr None None
Or NIHSS 8-9 with proven vessel occlusion (ICA, M1, BA)
SYNTHESIS EVT v IVT 362 (181 v 181) Feb 2008 – Apr 2012 Italy – 24 centres 18-80 yr NIHSS >25 excluded Not required at randomization <4.5 hr None None
PISTE Bridging v IVT 65 (33 v 32) Apr 2013-Apr 2015 10 Centres (UK) ≥18 yr NIHSS ≥6 I-ICA, M1, M2 Extra-cranial-ICA excluded <5.5 hr Evidence of extensive established infarction excluded None
THERAPY Bridging v IVT 108 (55 v 53) Mar 2012 - Oct 2014 36 Centres (US and Germany) 18-85 yr NIHSS ≥8 I-ICA, M1 eligible for tPA (<4.5 hr) Any acute ischemic changes >1/3 MCA excluded clot length ≥8 mm
MR CLEAN EVT v standard 500 (233 v 267) Dec 2010-Mar 2014 Netherlands - 16 centres ≥18 yr NIHSS ≥2 I-ICA,M1,M2,A1,A2 Additional extra-cranial ICA or dissection at discretion of treating physician <6 hr None None
ESCAPE EVT v standard 315 (165 v 150) Feb 2013-Oct 2014 22 Centres (Canada, US, Ireland, South Korea, Uk) ≥18 yr NIHSS >5 I-ICA,M1, 2-M2s, A1 Additional extracranial ICA or dissection at discretion of treating physician <12 hr ASPECTS >5 CTA filling >50% of MCA pial collaterals, CTP = vlCBF/CBV ASPECTS >5
EXTEND_IA Bridging v IVT (Solitaire only) 75 (35 v 35) Aug 2012-Oct 2014 10 centres (9 Aus, 1 NZ) ≥18 yr No NIHSS cut-off ICA, M1 or M2 dissection excluded <6 hr None Target mismatch: mismatch >1.2, rCBF core <70 ml, 6 sec Tmax penumbra >10 ml
SWIFT PRIME Bridging v IVT (Solitaire only) 196 (98 v 98) Dec 2012-Nov 2014 39 centres (US and Europe) 18-80 NIHSS 8-29 I-ICA, M1 Extra-cranial-ICA excluded (including dissection) <6 hr Revised small core (ASPECTS >5) Initially target mismatch (core <50 ml, 10 sec Tmax lesion <100 ml, penumbra >15 ml and mismatch ≥1.8)
REVASCAT EVT v standard (Solitaire only) 206 (103 v 103) Nov 2012-Dec 2014 4 centres Spain (Catalonia) 18-80 NIHSS?>?5 I-ICA,M1, <8 hr ASPECTS >6 (>5 on DWI) No recanalization on CTA/MRA after ≥30 min from start of tPA infusion If CTA/MRA performed >4.5 hr from onset then CBV ASPECTS, CTA-SI ASPECTS or DWI-MR ASPECTS must be performed
THRACE Bridging v IVT 412 (208 v 204) June 2010-Feb 2015 26 centres France (Mothership only model) 18-80 NIHSS 10-25 I-ICA, M1, upper 1/3 basilar artery, Ipsilateral E-ICA, stenosis/occlusion excluded <5 hr None None