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Table 4 Outcomes

From: An historical and contemporary review of endovascular therapy for acute ischemic stroke

  Recanalization (%, EVT v control) Reperfusion (mTICI 2b/3, %) Primary outcome mRS at day 90 mRS 0-2 at day 90 Final infarct volume (mL) sICH (PH-2, %) Death at day 90 (%) New AIS in a different territory (%) SAE (%)
MR RESCUE 69 27 mRS 3.8 v 3.4 3.8 v 3.4 21 v 26 32 v 32 9 v 6 18 v 21 1.4 62
IMS III 81 ICA; 86 M1; 88 M2 38 ICA; 44 M1; 44 M2 mRS 0-2 41 v 39% nr 41 v 39 nr 6 v 6 19 v 21 nr nr
SYNTHESIS nr nr mRS 0-1 30 v 35% nr 42 v 46 nr 6 v 6 8 v 6 nr nr
PISTE 69 87 OR 2.12 mRS 0-2 p = 0.2 nr 51 ϖ 40 νσ NNT = 9 nr 0 v 0 7 v 4 nr 45 v 34
THERAPY nr 70 mRS 0-2 38 v 30% p = 0.44 nr 38 v 30 ns nr 9.3 v. 9.7 12 v 24 nr 42 v 48
MR CLEAN 75 v 33 59 mRS 3v4 day 90 3 v 4 33 v 19 NNT = 7 49 v 79 6 v 5 21 v 22 5.6 47 v 42
ESCAPE nr v 31 (mAOL 2-3) 72 cOR 2.6 2 v 4 53 v 29 NNT = 4 nr 4 v 3 10 v 19 (significant) nr 21 v 18
EXTEND_IA 94 v 43 (TIMI 2-3) 86 24 hr reperfusion 100 v 37% Early neurological recovery 82 v 37% 1 v 3 71 v 40 NNT = 3 23 v 53 0 v 6 9 v 20 (p = 0.18) 5.7 nr
SWIFT PRIME nr 88 Shift analysis p = 0.0002 2 v 3 60 v 36 NNT = 4 nr 1 v 3 9 v 12 (p = 0.5) nr 36 v 31
REVASCAT nr 66 cOR 1.7 nr 44 v 28 NNT = 6 16 v 39 5 v 2 18 v 16 5 30 v 25
THRACE 78 69 mRS 0-2 at day 90 53v42% nr 53 v 42 NNT =9 nr 2 v 2 12 v 13 6 8 v 7
  1. EVT endovascular thrombectomy, tPA tissue plasminogen activator, Bridging IV tPA + thrombectomy, NIHSS National Institutes of Health Stroke Scale, I-ICA intracranial internal carotid artery, MCA middle cerebral artery, M1 first portion of the middle cerebral artery, from the origin to the bifurcation/trifurcation, M2 s portion of the middle cerebral artery, CTA Computer Tomography Angiography, CTP Computed Tomography Perfusion, vlCBV very low cerebral blood volume, ASPECTS Alberta Stroke Program Early CT Score, nr not recorded, mAOL modified arterial occlusion lesion score, TIMI thrombolysis in myocardial infarction score, mTICI modified thrombolysis in cerebral infarction score, mRS modified Ranking Scale, sICH symptomatic intracranial haemorrhage, PH-2 parenchymal hematoma 2, ie. >30% of the infarcted area with significant space-occupying effect, or clot remote from infarcted area, AIS acute ischemic stroke, SAE serious adverse events